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. 2015 Aug 25;6:878. doi: 10.3389/fmicb.2015.00878

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Copyright © 2015 Rom, Reichenbach, Dykstra and Persidsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PARP inhibition decreases HIV-1 reverse transcriptase (RT) activity and HIV-1 LTR activity in HIV-1 infected human macrophages (MDM). RT activity assays performed on HIV-infected MDM treated with PARPi or AZT either for 24 h prior to HIV infection (A) or immediately after (B) HIV infection. Treatments with PARP inhibitors (PARPi) or AZT were replenished every 12 h. The results are shown as the mean value ± SEM from three independent experiments utilizing MDM prepared from different donors. Data are presented as percent of HIV-only control. (^**p = 0.05, ^***p = 0.005, ^****p < 0.0001, ns = not significant).