Figure 3.

Inhibition of PARP diminishes secretion of p24 HIV-1 gag protein in human MDM infected with different HIV-1 strains. p24 ELISA was performed on supernatants from HIV-infected MDM treated with PARPi or AZT for 24 h prior to HIV infection. MDM were infected with M-tropic strains ADA (A) and JRFL (B) or the dual-tropic strain 89.6 (C). Treatments with PARP inhibitors (PARPi) or AZT were replenished every 24 h. The results are shown as the mean value ± SEM from three independent experiments utilizing MDM prepared from different donors. Data are presented as percent of HIV-only control. (^*p = 0.05, ^**p = 0.005, ^***p < 0.001, ns, not significant).