Figure 7.

PARP inhibitors suppress activation of small GTPases in MDM and affect actin rearrangements. (A) Representative histograms from flow cytometry analysis of F-actin and G-actin in MDM stimulated by addition of HIV_ADA for 5 min. MDM were treated with or without PARPi for 1 h prior to HIV_ADA introduction. Rho and Rac GTPase inhibitors, CT04, NSC, and Rho/Rac activator, CN04, used as controls. (B) Graphical representation of F-actin to G-actin ratios. The results are shown as the mean value ± SEM (^*p < 0.05 vs. HIV-stimulated but inhibitor untreated cells) from three independent experiments utilizing MDM prepared from different donors.