Table 2.
Studies of interferon-free regimens for treatment of hepatitis C virus positive liver transplant candidates
| Ref. | No. of patients | Severity of liver disease based on CP score | Antiviral scheme (duration) | Virological response |
| Curry et al[16] | 61 | ≤ 7 | SOF + RBV (for 48 wk or until LT) | 69% (12 wk after LT) |
| Afdhal et al[17] | 40 | 5-10 | SOF + RBV (48 wk) | 100% and 93% for Child class A and B, respectively at 24 wk under treatment |
| Gane et al[18] | 20 | 7-9 | SOF + Ledipasvir ± RBV(12 wk) | 89% |
| Flamm et al[19] | 108 | Decompensated cirrhosis (CP score range: 7-12) | Ledipasvir/SOF + RBV(12 or 24 wk) | 87% and 89% (for 12 and 24 wk, respectively) |
CP: Child-Pugh; SOF: Sofosbuvir; RBV: Ribavirin.