Table 1.
Clinical and autoantibody data of studied 22 PBC patients.
| Patient | Age | Stage | AMA | ANA | SP100 (LIPS) | SP140 (LIPS) | SP140L (LIPS) |
|---|---|---|---|---|---|---|---|
| P1 | 50 | III | 1 : 100 | — | + | + | — |
| P2 | 51 | II | — | 1 : 100 | + | + | + |
| P3 | 54 | II | 1 : 320 | — | — | — | — |
| P4 | 63 | IV | 1 : 100 | — | + | — | — |
| P5 | 54 | IV | 1 : 40 | — | — | — | — |
| P6 | 44 | III | 1 : 320 | — | + | — | — |
| P7 | 88 | III | 1 : 320 | — | — | + | — |
| P8 | 43 | II | 1 : 100 | — | — | — | — |
| P9 | 63 | IV | 1 : 160 | — | — | — | — |
| P10 | 65 | III | 1 : 100 | — | — | — | — |
| P11 | 66 | II | 1 : 100 | 1 : 10 | — | — | — |
| P12 | 42 | III | 1 : 100 | — | — | — | — |
| P13 | 61 | II | 1 : 100 | — | + | + | + |
| P14 | — | IV | 1 : 8000 | — | + | — | — |
| P15 | 79 | III | 1 : 4000 | — | + | — | + |
| P16 | 64 | III | 1 : 8000 | — | + | — | — |
| P17 | 59 | II | 1 : 8000 | — | — | — | — |
| P18 | 70 | II | 1 : 1000 | — | + | — | — |
| P19 | 49 | IV | 1 : 500 | — | + | — | — |
| P20 | 60 | I | 1 : 8000 | — | — | — | — |
| P21 | — | II | — | — | — | — | — |
| P22 | 72 | III | 1 : 200 | — | — | — | — |
PBC staging was performed by liver biopsy sample histology. Indirect immunofluorescence on rodent tissue slides was used for AMA (antimitochondrial antibodies) and ANA (antinuclear antibodies) detection at indicated serum dilutions. The LIPS assay is described in Methods.