TABLE 3.
Fasting and postprandial variables of glucose metabolism during the baseline meal study and after 6 and 12 wk of caloric restriction for patients with type 2 diabetes1
| Variables | Baseline study | 6 wk study | 12 wk study | P2 | Post hoc comparisons |
| Fasting EGP, μmol · kg−1 · min−1 | 20.4 ± 1.2 | 16.2 ± 0.8 | 17.4 ± 1.1 | 0.003 | BL > (6 wk = 12 wk) |
| Nadir EGP, μmol · kg−1 · min−1 | 5.9 ± 0.4 | 4.8 ± 0.2 | 5.1 ± 0.3 | 0.07 | NA |
| Peak Meal Ra, μmol · kg−1 · min−1 | 40.1 ± 3.0 | 32.1 ± 3.4 | 38.1 ± 3.7 | 0.33 | NA |
| AAB Meal Ra, mmol/kg × 6 h | 3.2 ± 0.3 | 3.0 ± 0.1 | 3.0 ± 0.3 | 0.82 | NA |
| Fasting Rd, μmol · kg−1 · min−1 | 20.7 ± 1.1 | 16.4 ± 0.8 | 18.6 ± 1.3 | <1 × 10−4 | BL > (6 wk = 12 wk) |
| Peak Rd, μmol · kg−1 · min−1 | 45.0 ± 3.3 | 38.7 ± 2.9 | 44.9 ± 2.6 | 0.33 | NA |
| AAB Rd, mmol/kg × 6 h | 6.4 ± 0.2 | 6.2 ± 0.4 | 6.1 ± 0.3 | 0.15 | NA |
1
Values are means ± SEMs, n = 9 except at 12 wk, n = 8. AAB, area above basal; BL, baseline; EGP, endogenous glucose production; NA, not applicable; Meal Ra, rate of meal appearance; Rd, rate of disappearance.
2
Determined by repeated-measures ANOVA.