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. 2015 Aug 25;9:319. doi: 10.3389/fncel.2015.00319

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Copyright © 2015 Vasaikar, Ghosh, Narain, Basu and Gomes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of HSPs in apoptosis network. The Boolean analysis was performed using HSP27, HSP40, HSP70, and HSP90 regulation in apoptotic network. The attractors were obtained by performing simulations under four different combinations of GF and FasL. (A) ON state of GF showed maximum states were in survival fate. The active state of HSP70 resulted in significantly increase in survival fate. (B) When FasL was active and GF was inactive, ON state of HSP27 and HSP70 resulted in reduced apoptosis states. (C) In the presence of both GF and FasL, more than 40% of states were in DNA repair fate and showed decreased apoptosis states in HSP27, HSP40, and HSP 70. The ON state of HSP70 showed more than 50% of states having survival fate. (D) When GF and FasL were in OFF state, HSP27and HSP70 showed more than 40% of states in survival states.