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. 2015 Aug 25;9:319. doi: 10.3389/fncel.2015.00319

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Copyright © 2015 Vasaikar, Ghosh, Narain, Basu and Gomes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vertex perturbation in apoptosis network. The graphical representation of cellular fates obtained after perturbation of node is shown. The OFF state of anti-apoptotic nodes such as AKT, BCL2, NFκB cFLIP, and IKK resulted in significant apoptosis states (red color). However, perturbation of pro-apoptotic nodes such as CASP3 and CASP8 resulted in maximum survival states (blue color). In case of BCL2, BID, BAX, and CYT-C mutation, few states were observed in DNA repair states shown in light green color.