Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	68 women, aged 25–45 years with regular periods, premenstrual distress for at least 6 months, diagnosis confirmed by prospective daily symptom rating assessment	Adverse effects with subcutaneous estradiol implant plus oral norethisterone with placebo implant plus oral placebo	Significance not reported