Table 2. VOCs discriminating the headspace of breast-derived cell lines.
| Trend | Class | Compound | CAS number | p value |
|---|---|---|---|---|
| Increase | Aromatic Amines | Pyrrolidine | 123-75-1 | 0.02 |
| Hydrocarbons | 2,3-Dimethylhexane, | 584-94-1 | 1.8 × 10−4 | |
| 2,4-Dimethyl-1-heptene | 19549-87-2 | 1.3 × 10−9 | ||
| 2,2-Dimethylbutane | 75-83-2 | 8.1 × 10−5 | ||
| 1,3-Di-tert-butylbenzene | 1014-60-4 | 1.8 × 10−9 | ||
| 2-Xylene | 95-47-6 | 0.77 | ||
| Ketons | 2-Nonanone | 821-55-6 | 6.5 × 10−21 | |
| 4-Methyl-2-heptanone | 6137-06-0 | 5.8 × 10−11 | ||
| 2-Dodecanone | 6175-49-1 | 3.6 × 10−3 | ||
| Carboxylic acid | Isobutyric acid, allyl ester | 15727-77-2 | 3.6 × 10−10 | |
| Fatty alcohol | 2-Ethylhexanol | 104-76-7 | 0.41 | |
| Decrease | Aromatic aldehyde | Benzaldehyde | 100-52-7 | 0.013 |
| Secondary alcohol | Cyclohexanol | 108-93-0 | 0.92 | |
| Manova | 1.6 × 10−16 |
Analysis of VOCs in the headspace of breast cell lines by GC-MS. Breast non-transformed and cancer cell lines were cultured at the same conditions. VOCs released (increase) or consumed/degraded (decrease) by breast cell lines are reported with respect to control medium. The p-values obtained by t-test analysis for each compound and by MANOVA analysis for all compounds are shown. A p-value < 0.05 has been considered statistically significant.