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. 2015 Aug 25;5:13524. doi: 10.1038/srep13524

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Simvastatin may activate EGFR–c-Src signaling to increase sEH Tyr phosphorylation, thus activating sEH phosphatase. This key event may negatively regulate simvastatin-activated Akt-AMPK-eNOS signaling and NO production in ECs.