Figure 9. Illustration of proposed mechanism of sEH phosphatase regulating simvastatin-induced eNOS activation and NO production in ECs.
Simvastatin may activate EGFR–c-Src signaling to increase sEH Tyr phosphorylation, thus activating sEH phosphatase. This key event may negatively regulate simvastatin-activated Akt-AMPK-eNOS signaling and NO production in ECs.