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. 2015 Jun 15;5(7):2113–2126.

Figure 1.

Figure 1

Sanger electropherograms representing DNA sequences of the two breast tumours with loss of the wild-type allele. A. In the peripheral blood, the patient carry the mutation MRE11 c.901C>G in the heterozygous state (last trace): 2 peaks, one blue (nulcleotide C) and one black (nulcleotide G). In the tumour (the 2 upper traces), there is no more allele with a C (blue trace) at position 901, the wild-type allele has disappeared. B. In the peripheral blood, the patient carry the mutation RAD51D c.853G>A in the heterozygous state (last trace). In the tumour, there is almost no more G at position 853. MRE11 c.901C>G and RAD51D c.853G>A loss of heterozygosity in the tumour.