Figure 1.

Antitumor efficacy and safety profile of evofosfamide in combination with mTOR inhibitors in 786-O and Caki-1 RCC xenograft models. A. Treatment schedule and experimental design; B-E. Tumor growth of evofosfamide in combination with mTOR inhibitors in the 786-O and Caki-1 xenograft models. Animals were monitored daily and tumor growth was quantified twice a week. Data are expressed as Mean ± SEM of 10 animals per group. Evo, evofosfamide; mTORi, mTOR inhibitor; Eve, everolimus; Tem, temsirolimus; CS, concurrent schedule; and DS, delayed schedule.