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. 2015 Jun 15;5(7):2139–2155.

Figure 4.

Figure 4

Effect of mTOR inhibitor on phosphorylated S6 ribosomal protein (pS6) expression. Everolimus and temsirolimus were used in the 786-O and Caki-1 xenografts, respectively. A. Representative images of pS6 immunostaining; B and C. Morphometric analysis of percentage of pS6 positive area inside the tumor. *, P < 0.05 as compared to Vehicle. a, P < 0.05 as compared to mTOR inhibitor monotherapy; b, P < 0.05 as compared to evofosfamide monotherapy. Each bar represents Mean ± SEM of 5-8 animals per group. Evo, evofosfamide; mTORi, mTOR inhibitor; Eve, everolimus; and Tem, temsirolimus.