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Summary of IC50 of evofosfamide alone, everolimus or temsirolimus alone, or in combination in 786-O and Caki-1 cells
| 786-O | Caki-1 | |||
|---|---|---|---|---|
|
|
||||
| Normoxia (21% O2) | Hypoxia (N2) | Normoxia (21% O2) | Hypoxia (N2) | |
|
|
||||
| IC50 (µM) | IC50 (µM) | IC50 (µM) | IC50 (µM) | |
| Evofosfamide | 84 | 2.5 | 63 | 0.5 |
| Everolimus | 81 | 48 | ||
| Temsirolimus | 18 | 16 | ||
| Evo + Eve | 140 | 11 | 71 | 0.4 |
| Evo + Tem | 150 | 2.8 | 120 | 3.9 |
Evo, evofosfamide; Eve, everolimus; Tem, temsirolimus.
