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. 2014 Sep 15;2(3):202–211. doi: 10.14218/JCTH.2014.00021

Table 2. Anti-HBV Agents and Reported Resistance Mutations.

Analog Type HBV polymerase mutation
Lamivudine Cytosine analog[(-)-β-L-2′-3′ dideoxythiacytidine] M204I/V, L180M, L180M-M204V, L180M-M204I
Adefovir Adenosine analog9-[2-[[bis[(pivaloyloxy)methoxy]-phosphinyl]methoxy]ethyl]adenine A181V/T, N236T, I233V
Entecavir Guanosine analog2-amino-1,9-dihydro-9-[(1S,3R,4S)-4hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one, monohydrate I169T, T184G, S202I, M250V, M204I/V
Telbivudine Thymidine analog1-(2-deoxy-β-L-ribofuranosyl)-5methyluracil M204I, L80I/V, L180M, A181 T/V, L229 W/V
Tenofovir Adenosine analog9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy) phosphinyl)methoxy)propyl) adenine fumarate (PMPA) A181V, N236T