Figure 4.

Comparison of enrichment of functional gene categories between drug-tolerant Mycobacterium tuberculosis in sputum and selected experimental models. A, Sputum after 14 days of drug treatment. B, Antibiotic selection model [11]. C, Hollow fiber artificial granuloma model [16]. D, Nutrient starvation model [13]. E, Oxygen deprivation nonreplicating persistence model [16], (F) Multiple-stress model [15]. Abbreviations: ATP, adenosine triphosphate; EHR, enduring hypoxic response; ESX, ESX/Type VII secretion system; IS & phages, insertion sequences and phage-related genes; TCA, tricarboxcylic acid cycle.