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. 2015 Oct;97:75–85. doi: 10.1016/j.neuropharm.2015.05.006

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 6 — The influence of a type I (NS-1738) and a type II PAM (TQS) on wild-type and mutated (L247T or M260L) α7 nAChRs. A) Representative traces illustrating responses with wild-type α7 nAChRs to acetylcholine (100 μM) and after the pre- and co-application of either NS-1738 (10 μM; Left pair of traces) or TQS (30 μM; Right). B) Representative traces illustrating responses with mutated (L247T) α7 nAChRs to acetylcholine (10 μM) and to NS-1738 (10 μM; Left) or TQS (30 μM; Right). C) Representative traces illustrating responses with mutated (M260L) α7 nAChRs to acetylcholine (100 μM) and NS-1738 (10 μM; Left) or TQS (30 μM; Right).