Fig. 8.

Antagonism of agonist responses to acetylcholine and TQS responses on M260L and L247T α7 nAChRs. A) Representative traces with M260L α7 nAChRs illustrating initial agonist responses with acetylcholine (1 mM) or TQS (10 μM) (left), antagonism by pre- and co-application of MLA (1 μM) (middle) and recovery in the absence of MLA (right). B) Representative traces with L247T α7 nAChRs illustrating initial agonist responses with acetylcholine (10 μM) or TQS (3 μM) (left), antagonism by pre- and co-application of MLA (1 μM) (middle) and recovery in the absence of MLA (right).