Skip to main content
. 2015 Aug 26;35(9):1963–1974. doi: 10.1161/ATVBAHA.115.305896

Figure 2.

Figure 2.

Senescent vascular smooth muscle cells (VSMCs) secrete cytokines and chemokines in an interleukin-1α (IL-1α)–dependent manner. Cytokine and chemokine content of conditioned media from control, replicative (A) and induced (B) senescent VSMC cultures measured by ELISA. IL-6 and IL-8 content of conditioned media from control and senescent VSMCs incubated ±neutralizing IL-1α (C and D) or IL-1β antibodies (E and F). Data represent mean±SEM of n=5 (AC, E, and F), 3 (D); *P≤0.05, **P≤0.02, and ***P≤0.005. NS indicates not significant.