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. 2015 Aug 26;35(9):1963–1974. doi: 10.1161/ATVBAHA.115.305896

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© 2015 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 7. — Senescent cells in human carotid plaques express interleukin-1α (IL-1α) and colocalize with IL-6 and CD68. Human carotid endarterectomy samples stained for senescence-associated β-galactosidase (SABG): showing senescent vascular smooth muscle cell (VSMC)-like cells in the fibrous cap that coexpress IL-1α (A); a discrete region containing many senescent cells showing localized IL-6 expression, in contrast to an adjacent region with no senescent cells or IL-6 (B); area within a fibrous cap (FC) showing high levels of local IL-6 expression adjacent to senescent cells (C); a large composite image showing localization between senescent and CD68 +ve cells (outlined and enlarged below; D); a region showing focal accumulation of senescent and CD68 +ve cells (E). Only eosin counterstain was used. Scale bars represent 100 and 25 mm (B; high power). L indicates lumen; and NC, necrotic core.