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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Br Med Bull. 2015 Mar 19;114(1):75–94. doi: 10.1093/bmb/ldv008

Table 4. Findings from case-control studies of soft tissue sarcoma.

Reference Exposure Factors of adjustment No. of exposed cases OR 95%CI Comments
Hardell et al 1979 [5] Phenoxyacetic acids for >1 day, >5 years before tumour diagnosis 13 5.3 2.4-11.5 Matching dissolved in analysis.
Eriksson et al 1981 [6] Phenoxy acids for >1 day, >5 years before tumour diagnosis 14 6.8 2.6-17.3 Matching dissolved in analysis.
Greenwald et al 1984 [43] Agent Orange, dioxin or 2,4,5-T 7 0.70 0.17-2.92
Hoar et al 1986 [44] Herbicides (including 2,4-D) Age 22 0.9 0.5-1.6
Vineis et al 1986 [46] “Definite” exposure to phenoxy acids Age, therapeutic X-rays, smoking 4 2.70 0.59-12.37 (90% CI) Risk estimate is derived from living women. Among living men, 0 cases and 2 controls were exposed.
Controls may not have been fully representative of source population because some municipalities and electoral offices did not respond.
Smith and Pearce 1986 [47] Probable or definite exposure to phenoxy herbicides for >1 day >5 years before registration Decade of birth, interview with subject or next of kin, phase of study 23 1.1 0.7-1.8 (90% CI)
Woods et al 1987 [50] Phenoxy herbicides (high) Age 0.89 0.4-1.9
Smith and Christophers 1992 [59] Exposure to phenoxy herbicides for ≥1 day >5 years before diagnosis (for controls, diagnosis of matched case) Sex, age, area of residence 1.3 0.4-4.1
Kogevinas et al 1995 [61] High cumulative exposure to phenoxy acids Sex, age and country 5 11.96 (1.03-701.9) Overlaps Kogevinas et al 1997 [22] and Lynge 1998 [31].
Pahwa et al 2011 [75] Use of phenoxy herbicides at work, in garden or for hobby Age, province, history of measles, rheumatoid arthritis, infectious mononucleosis, whooping cough or cancer in a first degree relative 80 1.09 (0.81-1.48)