Table 4. Findings from case-control studies of soft tissue sarcoma.
Reference | Exposure | Factors of adjustment | No. of exposed cases | OR | 95%CI | Comments |
---|---|---|---|---|---|---|
Hardell et al 1979 [5] | Phenoxyacetic acids for >1 day, >5 years before tumour diagnosis | 13 | 5.3 | 2.4-11.5 | Matching dissolved in analysis. | |
Eriksson et al 1981 [6] | Phenoxy acids for >1 day, >5 years before tumour diagnosis | 14 | 6.8 | 2.6-17.3 | Matching dissolved in analysis. | |
Greenwald et al 1984 [43] | Agent Orange, dioxin or 2,4,5-T | 7 | 0.70 | 0.17-2.92 | ||
Hoar et al 1986 [44] | Herbicides (including 2,4-D) | Age | 22 | 0.9 | 0.5-1.6 | |
Vineis et al 1986 [46] | “Definite” exposure to phenoxy acids | Age, therapeutic X-rays, smoking | 4 | 2.70 | 0.59-12.37 (90% CI) | Risk estimate is derived from living women. Among living men, 0 cases and 2 controls were exposed. Controls may not have been fully representative of source population because some municipalities and electoral offices did not respond. |
Smith and Pearce 1986 [47] | Probable or definite exposure to phenoxy herbicides for >1 day >5 years before registration | Decade of birth, interview with subject or next of kin, phase of study | 23 | 1.1 | 0.7-1.8 (90% CI) | |
Woods et al 1987 [50] | Phenoxy herbicides (high) | Age | 0.89 | 0.4-1.9 | ||
Smith and Christophers 1992 [59] | Exposure to phenoxy herbicides for ≥1 day >5 years before diagnosis (for controls, diagnosis of matched case) | Sex, age, area of residence | 1.3 | 0.4-4.1 | ||
Kogevinas et al 1995 [61] | High cumulative exposure to phenoxy acids | Sex, age and country | 5 | 11.96 | (1.03-701.9) | Overlaps Kogevinas et al 1997 [22] and Lynge 1998 [31]. |
Pahwa et al 2011 [75] | Use of phenoxy herbicides at work, in garden or for hobby | Age, province, history of measles, rheumatoid arthritis, infectious mononucleosis, whooping cough or cancer in a first degree relative | 80 | 1.09 | (0.81-1.48) |