Table 2.
IC50 values (μg/mL) of Taxol®, PTX-NP5K, and free PTX after 24, 48, and 72 hours incubation with A2780, A549, and MCF-7 cells at 37°C
| Incubation time | Taxol®
|
PTX-NP5K
|
Free PTX
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| A2780 | A549 | MCF-7 | A2780 | A549 | MCF-7 | A2780 | A549 | MCF-7 | |
| 24 hours | 2.40±0.34 | 7.83±0.46 | 1.35±0.05 | 3.97 ±0.12 | 20.69±1.94 | 17.0±1.52 | >100 | >100 | >100 |
| 48 hours | 0.50±0.08 | 4.86±0.60 | 0.13±0.12 | 1.12±0.01 | 5.05±0.24 | 0.31±0.06 | >100 | >100 | >100 |
| 72 hours | 0.05±0.01 | 0.11±0.02 | 0.03±0.01 | 0.19±0.07 | 0.46±0.08 | 0.20±0.06 | >25 | >25 | >25 |
Abbreviations: PTX, paclitaxel; NP, nanoparticles; IC 50, half maximal inhibitory concentration.