TABLE 1.
Biliary lipid compositions of pooled gallbladder bile during cholesterol crystallization
| Day | Ch (mol%) | PL (mol%) | BS (mol%) | Ch/PL Ratio | Ch/BS Ratio | [TL] (g/dl) | CSI |
| Wild-type | |||||||
| 0 | 2.47 | 11.50 | 86.03 | 0.215 | 0.029 | 8.94 | 0.56 |
| 3 | 3.28 | 12.68 | 84.03 | 0.259 | 0.039 | 8.77 | 0.70 |
| 6 | 5.03 | 13.31 | 81.66 | 0.378 | 0.062 | 9.45 | 1.01 |
| 9 | 5.74 | 15.15 | 79.12 | 0.379 | 0.073 | 9.46 | 1.05 |
| 12 | 6.83 | 16.27 | 76.91 | 0.420 | 0.089 | 9.84 | 1.17 |
| GPR30(−/−) | |||||||
| 0 | 1.98 | 10.68 | 87.34 | 0.185 | 0.023 | 8.76 | 0.47 |
| 3 | 2.29 | 13.05 | 84.66 | 0.175 | 0.027 | 8.69 | 0.48 |
| 6 | 3.56 | 14.27 | 82.17 | 0.250 | 0.043 | 8.67 | 0.70 |
| 9 | 5.16 | 13.96 | 80.88 | 0.370 | 0.064 | 8.81 | 1.01 |
| 12 | 6.10 | 15.77 | 78.13 | 0.387 | 0.078 | 10.48 | 1.06 |
| ERα(−/−) | |||||||
| 0 | 1.87 | 10.68 | 87.45 | 0.175 | 0.021 | 8.82 | 0.44 |
| 3 | 2.54 | 13.00 | 84.47 | 0.195 | 0.030 | 8.94 | 0.53 |
| 6 | 3.54 | 13.14 | 83.32 | 0.269 | 0.042 | 8.73 | 0.73 |
| 9 | 5.52 | 16.08 | 78.39 | 0.343 | 0.070 | 8.04 | 1.00 |
| 12 | 5.94 | 16.20 | 77.86 | 0.367 | 0.076 | 9.86 | 1.02 |
| GPR30(−/−)/ERα(−/−) | |||||||
| 0 | 1.55 | 11.35 | 87.09 | 0.137 | 0.018 | 8.22 | 0.36 |
| 3 | 2.19 | 12.06 | 85.75 | 0.181 | 0.025 | 8.47 | 0.49 |
| 6 | 2.78 | 15.05 | 82.17 | 0.184 | 0.034 | 8.35 | 0.53 |
| 9 | 3.39 | 15.91 | 80.70 | 0.213 | 0.042 | 8.49 | 0.62 |
| 12 | 4.09 | 17.45 | 78.46 | 0.234 | 0.052 | 9.26 | 0.69 |
Values were determined from pooled gallbladder bile (n = 5 per group). BS, bile salts; Ch, cholesterol; CSI, cholesterol saturation index; PL, phospholipids; [TL], total lipid concentration.