Table 1.
Contributions of the GABABR isoforms to cognition1
| Behavior | Direction | Knockout Genotype |
Publication |
|---|---|---|---|
| Familiar object recognition | Impaired | B1a | Vigot et al., 2006; Jacobson et al., 2007a |
| Novel object recognition | Impaired | B1a | Vigot et al., 2006; Jacobson et al., 2007a |
| Novel object recognition – consolidation | No effect | n/a | Cullen et al., 2014* |
| Novel object recognition – maintenance | Impaired | B1a | |
| Spontaneous alteration | Impaired | B1a, B1b | Jacobson et al., 2007a |
| Conditioned taste aversion – learning | Abolished | B1a | Jacobson et al., 2006a |
| Conditioned taste aversion – extinction | Impaired | B1b | |
| Conditioned fear – learning | Impaired, abolished | B1a, B1b | Shaban et al., 2006 |
| Conditioned fear – same context | No effect | n/a | Cullen et al., 2014* |
| Conditioned fear – different context | Impaired | B1a | |
| Passive avoidance learning | No effect | n/a | Jacobson et al., 2007a |
“Direction” indicates in comparison to wild type mice.
Asterisk (*) indicates that Cullen et al., (2014) only used wild type and B1a knockout mice.
“n/a” refers to “not applicable” in cases where no significant results were reported.