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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Neurosci Biobehav Rev. 2015 Aug 15;57:70–87. doi: 10.1016/j.neubiorev.2015.08.007

Table 5.

Anti-depressants and isoform mRNA expression5

Drug Region Direction Isoform Publication
Tranylcypromine (10 mg/kg) Hippocampus Increased B1a, B2 Sands et al., 2003
Phenelzine (10 mg/kg) Hippocampus Increased B1a
Fluoxetine (5 mg/kg) Hippocampus Increased B1a
Fluoxetine (5 mg/kg) Lumbar spinal cord Increased; Decreased B1a; B2 McCarson et al., 2006
Desipramine (15 mg/kg) Hippocampus Increased B1a Sands et al., 2003
Desipramine (15 mg/kg) Spinal cord dorsal horn Increased B1a, B2 Sands et al., 2004
Amitriptyline (10 mg/kg) Lumbar spinal cord Increased; Decreased B1a, B1b; B2 McCarson et al., 2006
5

Table 5 indicates the effects of different antidepressants on GABABR subunit and isoform expression. All results were gathered using in situ hybridization, and direction indicates a comparison to baseline. Tranylcypromine and phenelzine are MAOIs, fluoxetine is an SSRI, and desipramine and amitriptyline are tricyclics.