Table 4. Pathways contained in the change-then-stable category.

Tendency	Pathways	P-value	Differentially expressed genes
1	Fat digestion and absorption	7.04E-03	PPARA,PPAP2A,FABP2, PLA2G12B, APOB, APOA1
	PPAR signaling pathway	1.68E-04	APOA1, FABP4, ACSL5, PPARA, APOA1, FABP6, ACSBG2, FABP2, FABP4, RXRG
	Ether lipid metabolism	3.77E-02	PPAP2A, PLD1, PLA2G12B, PLB1
	Metabolic pathways	1.73E-04	NDUFS4, NDUFS5, PLB1, ALPL, CYP4F18, FUT9, GOT1, RFK, GGT5, LCT, POLE4, ASAH2, NDUFS1, COX6A1, NME3, CYP2R1, CYP27B1, COX5A, NDUFS6, ALPI, INPP5J, UCK2, NDUFB2, COX7C, GCDH, LCT, PGP, ATP6V1H, SAT2, GCH1, FASN, UQCRQ, LCMT2, NDUFA11, ACLY, ACSL5, NDUFB3, ACLY, COX6B1, NDUFA4, POLR2J, THTPA, PPAP2A, PLD1, UROD, ACSBG2, LIPASE, DBH, COX7B, ACACA, FBP2, ODC1, NT5C2, PHOSPHO1, LPIN1, GDA, URAH, COX6B1, LIAS, DCTD, GCK, PLA2G12B, DTYMK
	Fatty acid biosynthesis	2.36E-02	FASN, ACACA
	Ribosome	4.42E-14	RPS27L, RPS25, RPS15A, RPL28, RPS27A, RPS27RT, MRPS16, RPS12, RPS29, RPL26, RPS23, MRPS17, MRPS21, RPS27RT, RPL32, RPL35, RPS5, RPL13A, RPL37, RPL17, RPS10, RPL35A, RPL7A, RPS28, RPS19
	Proteasome	3.37E-02	PSMB6, SHFM1, PSMB4, PSMB9
	Vitamin digestion and absorption	3.37E-02	APOA1, APOA1, PLB1, APOB
	Folate biosynthesis	1.38E-02	ALPI, GCH1, ALPL
	Oxidative phosphorylation	3.31E-07	COX7A2, NDUFS1, COX6A1, COX5A, NDUFS6, NDUFB2, COX7C, ATP6V1H, UQCRQ, NDUFA11, NDUFB3, COX6B1, NDUFA4, COX7B, COX6B1, NDUFS4, NDUFS5
	Alzheimer's disease	8.00E-05	NDUFS4, NDUFS5, ERN1, COX7A2, NDUFS1, COX6A1,COX5A,NDUFS6, NDUFB2, COX7C, APOA1, UQCRQ, NDUFA11, NDUFB3, COX6B1, NDUFA4, COX6B1, COX7B
	Parkinson's disease	1.38E-05	COX6B1,NDUFS4,NDUFS5,COX5A, COX7A2,NDUFS1,COX6A1,UQCRQ, NDUFS6,NDUFB2,COX7C, COX7B, NDUFA11, NDUFB3, COX6B1, NDUFA4
	Non-alcoholic fatty liver disease (NAFLD)	1.36E-06	COX7B,COX6B1,NDUFS4,ERN1,NDUFS5,JUN, COX7A2, COX6A1, COX5A, NDUFS6, NDUFB2, COX7C, UQCRQ, NDUFA11, NDUFB3, COX6B1, NDUFA4, PPARA
	Huntington's disease	1.85E-04	COX6B1, NDUFA4, POLR2J, COX7B, COX6B1, NDUFS4, NDUFS5, COX7A2, NDUFS1, COX6A1, COX5A, NDUFS6, NDUFB2, COX7C, UQCRQ, NDUFA11, NDUFB3
	Cardiac muscle contraction	3.89E-06	ACTC1, COX6B1, COX7B, COX6B1, TNNC2, COX7A2, COX6A1, COX5A, TPM1, COX7C, MYH6, ATP1B1, MYL4, ACTC1, TNNT2, UQCRQ
	Dilated cardiomyopathy	4.86E-03	TNNT2, ITGA6, ACTC1, TNNC2, IGHV9, DES, ITGB4, TPM1, ITGB3, MYH6, ITGA6, ACTC1
	Hypertrophic cardiomyopathy (HCM)	7.40E-03	ITGA6, ACTC1, TNNT2, ITGA6, ACTC1, TNNC2, DES, ITGB4, TPM1, ITGB3, MYH6
	Small cell lung cancer	1.36E-02	RXRG,FHIT, RXRG,FHIT, TRAF5, ITGA6, CDK4, CDK4, ITGA6, LAMC3, MYC
	Pyrimidine metabolism	2.88E-02	POLE4, NME3, UCK2, POLR2J, NT5C2, DCTD, DTYMK
6	MicroRNAs in cancer	2.39E-03	CDKN1B, SOX12, CYP24A1, CD44, BMF, FSCN1
	Circadian rhythm—mammal	2.85E-02	PRKAG3
	Rheumatoid arthritis	3.20E-02	ANGPT1, H2-EA-PS, H2-EB2
	Asthma	3.55E-02	H2-EB2, H2-EA-PS
	Staphylococcus aureus infection	2.67E-02	H2-EA-PS, H2-EB2, ITGAX
	Cell cycle	4.97E-02	CDKN1B,STAG1,MCM6
	Purine metabolism	3.10E-02	NT5C2, ENTPD2, PDE1B, PDE6D
	Hematopoietic cell lineage	3.38E-02	ITGAX, CD44, H2-EB2
	Leishmaniasis	3.85E-02	ITGAX, H2-EA-PS, H2-EB2
	ECM-receptor interaction	3.85E-02	COL6A6, CD44, ITGA11