Table 2.
Proteins that were identified in rat TC and CSC culture supernatants using Luminex-xMAP
| Protein | Name | Alternative names | Molecular weight | UniProt KB code | Roles | Concentration, pg/ml | |
|---|---|---|---|---|---|---|---|
| TCs | CSCs | ||||||
| MIP-2 rat CXCL2 rat | CXC motif chemokine 2 | Macrophage inflammatory protein 2 | 31,307.36 (tetrameric) | P30348 | Chemotaxis | 67 ± 4.9 | 43 ± 6.2 |
| IL-6 rat | Interleukin-6 | IL-6 | 21,732.90 | P08505 | Positive regulation of ERK1 and ERK2 cascade Cytokine, Growth factor | 485 ± 19 | 82 ± 11 |
| VEGF rat | Vascular endothelial growth factor | VEGFA, VEGF | 22,077.47 | P16612 | Developmental protein, Growth factor, Mitogen Angiogenesis, Differentiation | 475 ± 31 | 304 ± 24 |
| MIP-1α | C-C motif chemokine 3 | Macrophage inflammatory protein 1-alpha MIP-1α | 7853.90 | P50229 | Chemotaxis, Inflammatory response | 22 ± 5.6 | 4 ± 0.8 |
| IL-2 rat | Interleukin-2 | IL-2 | 15,493.97 | P17108 | Positive regulation of tyrosine phosphorylation of Stat5 protein | 14.2 ± 0.9 | 13.5 ± 0.7 |
| IL-5 rat | Interleukin-5 | IL-5 | 13,074.22 | Q08125 | Positive regulation of cell proliferation | 69 ± 1.9 | 18 ± 2.6 |
| IL-13 rat | Interleukin-13 | IL-13 | 12,075.14 | P42203 | Positive regulation of connective tissue growth factor production | 7.2 ± 0.6 | 12.3 ± 0.8 |
| Negative regulation of neuron death | |||||||
| MCP-1 rat | Monocyte chemoattractant protein 1 | C-C motif chemokine 2 | 14,066.11 (dimer) | P14844 | Cellular response to fibroblast growth factor; organ regeneration | 1490 ± 55 | 467 ± 36 |
| Monocyte chemotactic protein 1 | Cellular response to macrophage colony-stimulating factor; | ||||||
| GRO-KC rat CXCL1 | Growth-regulated alpha protein | C-X-C motif chemokine 1 | 7849.37 × 2 | P14095 | Cytokine, Growth factor | 940 ± 41 | 539 ± 54 |
| IL-10 rat | Interleukin-10 | IL-10 | 18,640.56 | P29456 | Negative regulation of inflammatory response, inhibition of apoptosis | 18 ± 1.7 | 13 ± 2.1 |