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. 2015 Mar 8;19(8):1916–1928. doi: 10.1111/jcmm.12566

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The WF-208-indeced apoptosis was caspase-3-dependent. (A) The effects of WF-208 on caspase family proteins and PARP at different time were measured by Western blot analyses in HL-60 (left) and U-937 (right) cells. (B) The cytotoxicity of WF-208 on procaspase-3 silenced HL-60 cells (left) and procaspase-3 overexpressed MCF-7 cells (right) after 24 hrs treatment. *P < 0.05 compare with sham siRNA or control plasmid group. (C) The WF-208-induced cleavage of caspase-3 and PARP in procaspase-3 silenced HL-60 cells (left) and procaspase-3 overexpressed MCF-7 cells (right).