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. 2015 Jul 8;19(8):2006–2018. doi: 10.1111/jcmm.12581

Figure 2.

Figure 2

Genotyping the CPVT1 RyR2 R420Q mutation and CPVT2 CASQ2 D307H mutation. (A) Sequence chromatograms from the CPVT1 iPSC-HF15.1 and 15.4 clones (WT/M), and from a healthy non-carrier iPSC-KTN3 clone (WT/WT). The analysis shows a G to A substitution at nucleotide 1378 in exon 13, converting an arginine amino acid to glutamine at position 420 of the protein. (B) Sequence chromatograms from the CPVT2 iPSC-HDF19.1, 20.1 clones (M/M) and a healthy non-carrier iPSC-KTN3 clone (WT/WT). There is a G to C substitution at nucleotide 1183 in exon 9, converting aspartic acid to histidine at codon 307.

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