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. 2015 Jul 8;19(8):2006–2018. doi: 10.1111/jcmm.12581

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The effects of isoproterenol on the [Ca⁺²]_i transients in control, CPVT1and CPVT2 iPSC-CM. (A) [Ca⁺²]_i transients from control (clone 24.2 day 54) iPSC-CM paced at 0.5 Hz, in the absence and presence of isoproterenol. (B–D) Representative experiments in CPVT1 and CPVT2 iPSC-CM demonstrating the 3 types of responses to isoproterenol. Left side: CPVT1 (clones 15.4 day 56, 15.1 day 49, 15.1 day 38) iPSC-CM; Right side: CPVT2 iPSC-CM (clones 20.1 day 67, 19S1 day 43, 12.1 day 39). (B) No response to isoproterenol. (C) Isoproterenol induced triggered beats, marked by the arrows. (D) Isoproterenol increased diastolic [Ca⁺²]_i. In (B–D) the pacing rates are shown in each panel. Arrhythmias are marked by black arrows.

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