Figure 7.

Summary of the effects of isoproterenol on the [Ca²⁺]_i transients of control, CPVT1 and CPVT2 iPSC-CM. (A) [Ca⁺²]_i transient amplitude; (B) Diastolic [Ca²⁺]_i; (C) +d[Ca²⁺]_i/dt; (D) −d[Ca²⁺]_i/dt. In (A, C and D), the effect of isoproterenol was expressed as per cent change from control, and in (B), the effect was expressed as the change in the fluorescence ratio, Δ_340/380, *P < 0.05, **P < 0.001. Asterisks above columns represent statistically significant effect of isoproterenol. The statistical analysis of differences among groups is shown in the Table below: C - Control iPSC-CM (n = 8), C1 - CPVT1 iPSC-CM (n = 12), C2 - CPVT2 iPSC-CM (n = 19).