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. 2015 Aug 25;16(1):174. doi: 10.1186/s13059-015-0747-5

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© Mattout et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Histone modifications regulate perinuclear sequestration. A model of known and suggested histone tail modifications involved in heterochromatin anchoring at the nuclear envelope. The deposition of histones carrying H3K9^me1 or H3K9^me2 could be sufficient to ensure localization at the nuclear envelope according to work with the worm Caenorhabditis elegans [74]. Potential methyl readers that might contribute to anchoring include the lamin B receptor (LBR) in mammals and a C. elegans chromodomain protein (CEC-x) in worms. Readers of the H3K9^me3 modification that ensure silencing include worm homologs of heterochromatin protein 1 (HP1) and LIN-61. Other factors implicated in tissue-specific gene repression and sequestration include cKROX and HDAC3, or an unknown reader of H4K20me3. See text for further details