Table 2.
Baseline characteristics in the two glucose-6-phosphate dehydrogenase groups
| Parameter | G6PD deficient | G6PD normal | P value |
|---|---|---|---|
| n = 18 | n = 57 | ||
| Age (years) | 25 (5–56) | 24 (7–63) | 0.95 |
| Aged <18 years | 5 (27.8) | 10 (17.5) | 0.34 |
| Male, female | 15 (83.3), 3 | 48 (84.2), 9 | 0.93 |
| Weight (kg) | 54 (20–56) | 53 (14–88) | 0.83 |
| Symptoms | |||
| Headache | 14 (77.8) | 53 (92.9) | 0.07 |
| Fever | 14 (77.8) | 48 (84.2) | 0.53 |
| Chills | 12 (66.7) | 47 (82.5) | 0.15 |
| Abdominal pain | 4 (22.2) | 28 (49.1) | 0.04 |
| Nausea | 3 (16.7) | 14 (24.6) | 0.48 |
| Cough | 1 (5.6) | 7 (12.3) | 0.42 |
| Abnormal urine colour | 9 (50) | 7 (12.3) | 0.001 |
| Signs | |||
| Mean (SD) temperature (°C) | 37.8 (0.9) | 38.6 (1.0) | 0.002 |
| Mean (SD) pulse (mmHg) | 92 (18.6) | 96 (11.1) | 0.32 |
| Mean (SD) systolic BP (mmHg) | 105 (15.5) | 110 (12.4) | `0.17 |
| Mean (SD) diastolic BP (mmHg) | 61 (11) | 66 (10) | 0.09 |
| Normal conjunctival colour | 18 (100) | 56 (98.3) | 0.57 |
| Pale palms | 1 (5.6) | 5 (8.8) | 0.66 |
| Palpable liver | 1 (5.6) | 2 (3.5) | 0.69 |
| Palpable spleen | 1 (5.6) | 2 (3.5) | 0.69 |
| Haematological parameters | |||
| G6PD activity (U/g Hb) | 0.85 (0.1–1.5)a | 12 (6.9–18.5) | 0.000 |
| Normal haemoglobin | 11 (61.1) | 31 (54.4) | |
| Heterozygous HbE | 5 (27.8) | 20 (35.1) | |
| Homozygous HbE | 0 | 1 (1.75) | |
| Alpha/beta thalassaemia | 1 (5.6) | 5 (8.7) | 0.4 |
| Haemoglobin (g/dL) | 13.0 (9.6–16) | 13.5 (9–16.3) | 0.46 |
| Total white cell count ×103/μL | 5.15 (1.4–8.3) | 5.0 (1.1–11.5) | 0.61 |
| Platelet count ×103/μL | 126 (42–187) | 99 (12–204) | 0.26 |
| Vivax parasitaemia/μL | 6,420 (159–9326) | 7,888 (220–59,542) | 0.13 |
Unless otherwise stated, continuous data are shown as median (range)
Proportional data are shown as N (%)
BP blood pressure, G6PD glucose-6-phosphate dehydrogenase HbE haemoglobin E, SD standard deviation
asubstituting the two missing enzyme values with post D0 values: 0.9 (0.1–2.6) U/g Hb