Table 2.
Functional clustering of genes derived using the DAVID gene functional classification tool
| ES | Term in DAVID | n | p value | FE | q-value |
|---|---|---|---|---|---|
| 4.2 | GO:0010558 ~ negative regulation of macromolecule biosynthetic process | 40 | 3.7E-05 | 2.0 | 7.9E-3 |
| GO:0031327 ~ negative regulation of cellular biosynthetic process | 40 | 6.0E-05 | 2.0 | 1.1E-2 | |
| GO:0009890 ~ negative regulation of biosynthetic process | 40 | 9.3E-05 | 1.9 | 1.6E-2 | |
| 3.8 | GO:0016279 ~ protein-lysine N-methyltransferase activity | 7 | 5.0E-05 | 9.7 | 5.1E-3 |
| GO:0016278 ~ lysine N-methyltransferase activity | 7 | 5.0E-05 | 9.7 | 5.1E-3 | |
| GO:0018024 ~ histone-lysine N-methyltransferase activity | 7 | 5.0E-05 | 9.7 | 5.1E-3 | |
| GO:0042054 ~ histone methyltransferase activity | 7 | 3.0E-04 | 7.2 | 2.3E-2 | |
| GO:0008276 ~ protein methyltransferase activity | 7 | 2.5E-03 | 5.0 | 7.7E-2 | |
| 3.3 | GO:0000377 ~ RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 15 | 4.8E-04 | 3.0 | 6.0E-2 |
| GO:0000375 ~ RNA splicing, via transesterification reactions | 15 | 4.8E-04 | 3.0 | 6.0E-2 | |
| GO:0000398 ~ nuclear mRNA splicing, via spliceosome | 15 | 4.8E-04 | 3.0 | 6.0E-2 | |
| 3.3 | IPR000504:RNA recognition motif, RNP-1 | 17 | 4.0E-04 | 2.8 | 3.1E-1 |
| SM00360:RRM | 17 | 5.1E-04 | 2.7 | 9.8E-2 | |
| IPR012677:Nucleotide-binding, alpha-beta plait | 17 | 6.1E-04 | 2.7 | 2.5E-1 | |
| 2.3 | GO:0006099 ~ tricarboxylic acid cycle | 6 | 1.7E-03 | 6.6 | 1.5E-1 |
| GO:0046356 ~ acetyl-CoA catabolic process | 6 | 2.1E-03 | 6.3 | 1.7E-1 | |
| GO:0009109 ~ coenzyme catabolic process | 6 | 3.7E-03 | 5.6 | 2.3E-1 | |
| GO:0009060 ~ aerobic respiration | 6 | 4.4E-03 | 5.4 | 2.5E-1 | |
| GO:0051187 ~ cofactor catabolic process | 6 | 8.1E-03 | 4.7 | 3.4E-1 | |
| rno00020:Citrate cycle (TCA cycle) | 6 | 9.2E-03 | 4.5 | 1.7E-1 | |
| GO:0006084 ~ acetyl-CoA metabolic process | 6 | 1.9E-02 | 3.8 | 4.7E-1 | |
| 2.2 | GO:0030964 ~ NADH dehydrogenase complex | 5 | 3.7E-03 | 7.5 | 7.1E-2 |
| GO:0045271 ~ respiratory chain complex I | 5 | 3.7E-03 | 7.5 | 7.1E-2 | |
| GO:0005747 ~ mitochondrial respiratory chain complex I | 5 | 3.7E-03 | 7.5 | 7.1E-2 | |
| GO:0005746 ~ mitochondrial respiratory chain | 5 | 4.3E-02 | 3.7 | 3.1E-1 | |
| 2.1 | GO:0016571 ~ histone methylation | 6 | 1.4E-03 | 6.9 | 1.3E-1 |
| GO:0008213 ~ protein amino acid alkylation | 6 | 1.9E-02 | 3.8 | 4.7E-1 | |
| GO:0006479 ~ protein amino acid methylation | 6 | 1.9E-02 | 3.8 | 4.7E-1 | |
| 2.1 | IPR001440:Tetratricopeptide TPR-1 | 9 | 4.5E-03 | 3.4 | 5.8E-1 |
| IPR019734:Tetratricopeptide repeat | 9 | 1.0E-02 | 2.9 | 7.2E-1 | |
| SM00028:TPR | 9 | 1.2E-02 | 2.8 | 5.7E-1 |
The rat genome was used as a background list to calculate the p-values of each term. A total of 868 genes were recognised. The p-values were calculated according to a modified Fisher’s exact test (EASE score). The q-values were calculated according to the Benjamini-Hochberg method. Cluster enrichment scores (ES) and fold enrichment (FE) rank overall importance (enrichment) of gene groups or the statistically most overrepresented (enriched) biological annotations. The highest classification stringency was used