Table 3. Genes in the putative lomofungin biosynthesis cluster.

ORFs	aa	Proposed function	Identity (%)	Ortholog identified by BLAST search
lomo1	201	Shikimate kinase	88%	Streptomyces fulvoviolaceus
lomo2	378	Chorismate synthase	97%	Streptomyces fulvoviolaceus
lomo3	272	3-phosphoshikimate- 1-carboxyvinyltransferase	78%	Streptomyces sp. NRRL B-5680
lomo4	306	5,10-methylenetetrahydrofolate reductase	90%	Streptomyces sp. NRRL S-646
lomo5	203	Hexokinase	71%	Streptomyces albaduncus
lomo6	398	S-adenosylmethionine synthetase	90%	Streptomyces sp. NRRL S-646
lomo7	201	Quinone oxidoreductase	78%	Streptomyces anulatus
lomo8	162	Flavin reductase	85%	Streptomyces sp. NRRL S-646
lphzG	213	phzG	53%	Pseudomonas chlororaphis GP72
lphzF	278	phzF	66%	Pseudomonas chlororaphis GP72
lphzE	598	phzE	63%	Pseudomonas chlororaphis GP72
lphzD	111	phzD	65%	Pseudomonas chlororaphis GP72
lphzC	368	phzC	60%	Pseudomonas chlororaphis GP72
lphzB	160	phzB	72%	Pseudomonas chlororaphis GP72
lomo9	354	Acyl-CoA dehydrogenase	95%	Streptomyces sp. NRRL S-646
lomo10	442	Flavin-dependent monooxygenase	48%	Streptomyces viridosporus
lomo11	273	Methyltransferase	39%	Streptomyces auratus
lomo12	342	Transcriptional regulator	94%	Streptomyces sp. NRRL S-646
lomo13	484	Transporter	91%	Streptomyces sp. NRRL S-646
lomo14	314	Alcohol dehydrogenase	89%	Streptomyces sp. NRRL S-646
lomo15	340	EsmB1, phenazine antibiotic biosynthesis protein	72%	Streptomyces antibioticus
lomo16	435	Aldehyde dehydrogenase	86%	Streptomyces sp. NRRL S-646
lomo17	337	Transcriptional regulator	86%	Streptomyces sp. NRRL S-646