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. 2014 Jul 24;18:9. doi: 10.1186/2055-7124-18-9

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© Yoo et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Lymphocytic infiltrates in salivary glands of NOD mice. A–E: H&E staining showing lymphocytic infiltration size (shown by yellow line and arrows) in NOD that were: untreated (A), CFA-treated (B), MSC + CFA (C), MSC (D). In 2 of the 5 NOD mice transplanted with MSCs only, no lymphocytic infiltrates were noted (E). Scale bar: 140 um for all images. (F): Salivary flow rates (SFRs) of NOD mice. SFRs in MSC + CFA (black circle; n = 10) and MSC (black square; n = 5) groups did not decrease during the follow-up period (22 wk of age) and were significantly higher than SFRs of CFA-treated or control NOD groups (n = 5 per group; P < 0.05). SFRs in CFA (triangular) or control (untreated; open circle) groups continued to decrease during the follow-up period (*P < 0.05). Reproduced with permission from: [35].