Fig 4. Effects of TLCA on HDAC4 expression in cultured primary HSCs.

TLCA increased HDAC4 expression (A) and nuclear translocation (B) in HSCs of WT mice (white bar). HSCs of miR-29a transgenic mice (gray bar) exhibited significantly reduced upregulation and nuclear translation of HDAC4 in response to TLCA stimulation. Data are expressed as the mean ± SE of four independent experiments. *indicates a p < 0.05 between the groups.