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. Author manuscript; available in PMC: 2016 Sep 16.
Published in final edited form as: Brain Res. 2015 May 9;1620:153–168. doi: 10.1016/j.brainres.2015.04.056

Fig. 1.

Fig. 1

Microvascular density changes associated with Alzheimer’s disease (AD) and ageing in hippocampus and cortex. Brain sections of APP/PS1 transgenic mice, a mouse model of AD, and C57BL/6 wild-type (WT) mice at 6, 12–14 and 23–28 months (young adulthood, middle-age and old mice, respectively) were processed for immunohistochemical analysis of the endothelial marker, cluster of differentiation 31 (CD31). Representative immunohistological patterns of CD31 in hippocampus (A) and cortex (B), where arrows point to CD31 positive microvessels. Semi-quantitative analysis of the area of blood vessels per brain area in hippocampus (C) and cortex (D). *P<0.05, **P<0.01 between indicated groups; #P<0.05, ##P<0.01 vs. age-matched WT.