Table 3.
Cause-Specific Cumulative Incidence of Mortality According to Baseline eGFR
| Type of Death (N = 806) | Q1: 0.9-24.2 (n = 1,008) | Q2: 24.3-31.6 (n = 1,014) | Q3: 31.7-40.2 (n = 1,007) | Q4: 40.3-119.8 (n = 1,006) | P Value |
|---|---|---|---|---|---|
| Overall | 30.6% (27.3%-34.0%) | 21.1% (18.3%-24.0%) | 18.9% (16.2%-21.8%) | 18.2% (15.4%-21.1%) | <0.001 |
| CV death | 15.4% (12.9%-18.0%) | 11.1% (9.1%-13.4%) | 11.2% (9.0%-13.6%) | 10.3% (8.2%-12.7%) | <0.001 |
| Fatal MI | 2.1% (1.3%-3.2%) | 1.9% (1.1%-3.2%) | 0.8% (0.4%-1.6%) | 1.1% (0.6%-2.0%) | 0.06 |
| Fatal stroke | 1.3% (0.7%-2.3%) | 1.5% (0.8%-2.4%) | 1.0% (0.5%-1.9%) | 0.6% (0.2%-1.4%) | 0.03 |
| Presumed CV death | 1.9% (1.1%-3.1%) | 1.4% (0.8%-2.5%) | 1.7% (0.9%-2.9%) | 1.3% (0.7%-2.3%) | 0.3 |
| Pump failure | 2.4% (1.5%-3.7%) | 1.7% (1.0%-2.7%) | 1.3% (0.7%-2.3%) | 2.3% (1.3%-3.7%) | 0.5 |
| CV other | 0.5% (0.2%-1.3%) | 1.0% (0.5%-1.9%) | 0.6% (0.2%-1.4%) | 0.8% (0.3%-1.5%) | 0.7 |
| Presumed sudden death | 1.4% (0.7%-2.4%) | 0.7% (0.3%-1.4%) | 1.5% (0.8%-2.7%) | 0.4% (0.1%-1.1%) | 0.3 |
| Definite sudden death | 5.7% (4.2%-7.6%) | 2.9% (1.9%-4.2%) | 4.2% (2.9%-5.8%) | 3.8% (2.6%-5.4%) | 0.07 |
| Definite or presumed sudden death | 7.1% (5.4%-9.1%) | 3.6% (2.5%-5.0%) | 5.7% (4.2%-7.6%) | 4.2% (2.9%-5.9%) | 0.04 |
| Non-CV death | 12.7% (10.4%-15.2%) | 8.4% (6.5%-10.5%) | 6.7% (5.1%-8.6%) | 6.1% (4.5%-8.0%) | <0.001 |
| Infection | 4.9% (3.5%-6.6%) | 2.7% (1.7%-3.9%) | 2.0% (1.2%-3.2%) | 1.5% (0.8%-2.7%) | <0.001 |
| Malignancy | 1.9% (1.1%-3.1%) | 2.2% (1.3%-3.4%) | 1.4% (0.8%-2.4%) | 1.8% (1.0%-3.0%) | 0.5 |
| Other | 4.0% (2.8%-5.5%) | 2.6% (1.6%-4.0%) | 2.4% (1.6%-3.7%) | 2.3% (1.4%-3.5%) | 0.03 |
| Renal | 1.9% (1.0-3.2) | 0.9% (0.4-1.8) | 0.8% (0.4-1.7) | 0.5% (0.1-1.5) | 0.01 |
| Unknown | 2.5% (1.6-3.9) | 1.6% (0.8-2.7) | 1.0% (0.5-2.0) | 1.7% (0.9-2.8) | 0.2 |
Note: eGFR quartiles expressed in mL/min/1.73 m2. Values are given as estimated cumulative incidence rate at 3 years (95% confidence interval). P value for trend test refers to risk of death across all patient follow-up for each cause of death across eGFR quartiles. Renal deaths defined as refusal of dialysis therapy or death in the setting of acute kidney injury or from direct complications of uremia, dialysis, or renal procedure. Other deaths include suicide and deaths from pulmonary, hepatobiliary, gastrointestinal, procedural, and accidental causes.
Abbreviations: CV, cardiovascular; eGFR, estimated glomerular filtration rate; MI, myocardial infarction; Q, quartile.