Table 5.

Multivariable Adjusted Competing Risks of Cause-Specific Mortality According to Baseline eGFR

Type of Death	Q1: 0.9-24.2 (n = 1,008)	Q2: 24.3-31.6 (n = 1,014)	Q3: 31.7-40.2 (n = 1,007)	P
Overall	1.83 (1.50-2.23)	1.23 (0.99-1.51)	1.08 (0.87-1.34)	<0.001
CV death	1.53 (1.17-1.99)	1.16 (0.88-1.54)	1.11 (0.84-1.48)	0.002
Fatal MI	1.55 (0.79-3.05)	1.15 (0.55-2.42)	0.60 (0.25-1.43)	0.09
Fatal stroke	2.71 (0.97-7.57)	2.60 (0.92-7.35)	1.96 (0.66-5.80)	0.04
Presumed CV death	1.42 (0.67-3.04)	1.29 (0.61-2.74)	1.16 (0.52-2.59)	0.3
Pump failure	1.17 (0.62-2.22)	1.04 (0.54-2.01)	0.81 (0.41-1.62)	0.5
CV other	0.52 (0.15-1.78)	1.40 (0.51-3.82)	0.73 (0.23-2.30)	0.6
Presumed sudden death	1.99 (0.75-5.27)	0.96 (0.32-2.91)	1.86 (0.70-4.95)	0.4
Definite sudden death	1.62 (1.03-2.54)	0.91 (0.54-1.53)	1.28 (0.79-2.07)	0.1
Definite or presumed sudden death	1.69 (1.12-2.54)	0.92 (0.58-1.47)	1.38 (0.90-2.12)	0.06
Non-CV death	2.11 (1.52-2.93)	1.31 (0.92-1.86)	1.04 (0.71-1.51)	<0.001
Infection	2.74 (1.50-5.02)	1.74 (0.90-3.34)	1.16 (0.56-2.37)	<0.001
Malignancy	1.16 (0.56-2.37)	1.30 (0.66-2.55)	0.73 (0.34-1.57)	0.4
Other	1.81 (1.06-3.09)	0.93 (0.50-1.71)	0.97 (0.54-1.77)	0.04
Renal	4.57 (1.33-15.74)	2.00 (0.52-7.64)	2.35 (0.62-8.85)	0.01
Unknown	1.52 (0.77-3.00)	1.18 (0.58-2.41)	0.99 (0.47-2.10)	0.2

Note: Values are given as hazard ratio (95% confidence interval). eGFR quartiles expressed in mL/min/1.73 m²; Q4 (40.3-119.8 mL/min/1.73 m²) is reference group (n = 1,006). Multivariable competing-risks models for specific causes of death. All models adjusted for for treatment, age, race, sex, diabetes, duration of diabetes, systolic and diastolic blood pressure, and history of CV disease.

Abbreviations: CV, cardiovascular; eGFR, estimated glomerular filtration rate; MI, myocardial infarction; Q, quartile.