Table 7.
Proportions of Deaths Due to Specific Causes According eGFR
| Type of Death (N = 806) | Q1: 0.9-24.2 (n = 1,008) | Q2: 24.3-31.6 (n = 1,014) | Q3: 31.7-40.2 (n = 1,007) | Q4: 40.3-119.8 (n = 1,006) | P |
|---|---|---|---|---|---|
| Overall | 275 | 200 | 175 | 156 | |
| CV death | 141 (51.27) | 109 (54.50) | 102 (58.29) | 89 (57.05) | 0.2 |
| Fatal MI | 22 (8.00) | 16 (8.00) | 8 (4.57) | 13 (8.33) | 0.7 |
| Fatal stroke | 14 (5.09) | 13 (6.5) | 10 (5.71) | 5 (3.21) | 0.5 |
| Presumed CV death | 17 (6.18) | 16 (8.00) | 14 (8.00) | 11 (7.05) | 0.7 |
| Pump failure | 21 (7.64) | 19 (9.50) | 15 (8.57) | 17 (10.90) | 0.3 |
| CV other | 4 (1.45) | 10 (5.00) | 5 (2.86) | 7 (4.49) | 0.2 |
| Presumed sudden death | 12 (4.36) | 6 (3.00) | 11 (6.29) | 6 (3.85) | 0.8 |
| Definite sudden death | 51 (18.55) | 29 (14.50) | 39 (22.29) | 30 (19.23) | 0.5 |
| Definite or presumed sudden death | 63 (22.91) | 35 (17.50) | 50 (28.57) | 36 (23.08) | 0.4 |
| Non-CV death | 112 (40.73) | 74 (37.00) | 59 (33.71) | 53 (33.97) | 0.1 |
| Infection | 41 (14.91) | 26 (13.00) | 17 (9.71) | 14 (8.97) | 0.04 |
| Malignancy | 17 (6.18) | 20 (10.00) | 12 (6.86) | 15 (9.62) | 0.3 |
| Other | 39 (14.18) | 21 (10.50) | 22 (12.57) | 21 (13.46) | 0.8 |
| Renal | 15 (5.45) | 7 (3.50) | 8 (4.57) | 3 (1.92) | 0.1 |
| Unknown | 22 (8.00) | 17 (8.50) | 14 (8.00) | 14 (8.97) | 0.8 |
Note: Values are given as number (percentage) of deaths due to specific causes within eGFR quartiles. eGFR quartiles expressed in mL/min/1.73 m2. P values are for trend in percent of deaths attributable to each cause across eGFR quartiles. Renal deaths defined as refusal of dialysis therapy or death in the setting of acute kidney injury or from direct complications of uremia, dialysis, or renal procedure. Other deaths include suicide and deaths from pulmonary, hepatobiliary, gastrointestinal, procedural, and accidental causes.
Abbreviations: CV, cardiovascular; eGFR, estimated glomerular filtration rate; MI, myocardial infarction; Q, quartile.