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. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Jun 17;287(3):240–245. doi: 10.1016/j.taap.2015.06.008

Fig. 1.

Fig. 1

Activations of p53 and p21 upon acute exposure of BEAS-2B cells to arsenic. A, p53 and p21 activity. BEAS-2B cells were transfected with either p53 or p21 luciferase report for overnight, followed by treatment with arsenic at doses of 2.5 μM and 5.0 μM for 24 hr. The cells were harvested for luciferase assay. B, BEAS-2B cells were treated with 2.5 μM and 5.0 μM of arsenic for 24 hr. RNA was isolated from the cells and subjected for RT-PCR analysis. C, BEAS-2B cells were treated with 2.5 μM and 5.0 μM of arsenic for 24 hr and 48 hr. Whole cell lysate was prepared for immunoblotting. *, p<0.05 compared to control group without arsenic treatment.