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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Ophthalmology. 2015 Jul 18;122(9):1939–1945.e2. doi: 10.1016/j.ophtha.2015.06.003

Table 3.

Weight Change Effects on OCT Outcomes in Study Eyes at Month Six

Label Weight Change Group Adjusted Mean (SE) Change from Baseline Weight Change Effect 95% CI p-value
3D-Segmentation Method Derived Measures
Total Volume ONH (mm3) Loss
No Change		 −4.2 (0.4)
−2.4 (0.4)		 −1.8 −2.8, −0.7 0.002
Average RNFL (μm) Loss
No Change		 −153.3 (14.2)
−96.4 (13.5)		 −56.9 −96.4, −17.4 0.01
Average TRT (μm) Loss
No Change		 −197.8 (17.5)
−119.5 (16.6)		 −78.3 −127.0, −29.7 0.002
Average GCL+IPL (μm) Loss
No Change		 −3.4 (0.5)
−2.0 (0.5)		 −1.4 −2.8, −0.001 0.05
ZM Algorithm Derived Measures
Average RNFL (μm) Loss
No Change		 −125.2 (13.1)
−73.5 (12.6)		 −51.7 −88.5, −15.0 0.01
Average TRT (μm) Loss
No Change		 −165.3 (15.8)
−97.5 (15.0)		 −67.8 −112.2, −23.4 0.003
Average GCL+IPL (μm) Loss
No Change		 6.2 (1.5)
5.7 (1.4)		 0.5 −3.8, 4.8 0.83

Weight change effects are the group differences (loss-no change) in adjusted mean response.