. 2015 Aug 25;10(8):e0134671. doi: 10.1371/journal.pone.0134671

Table 1. Summary of RELN-related findings in schizophrenia.

Study	Type of study	SampleSize S/C	RELN mRNA Conc.	RELN Blood Conc.	mRNA DNMT1 in GCN	Findings
Fatemi et al. 2005	Post mortem study of brain tissue	15/15	^↓CBL	n/a	n/a	p<0.05 vs. controls
Habl et al. 2012	Post mortem study of brain tissue	12/13	^↓PFC, left	n/a	n/a	p = 0.022 vs. controls in white matter
Habl et al. 2012	Post mortem study of brain tissue	12/13	^↓PFC, left	n/a	n/a	p = 0.007 vs. controls in gray matter
Impagnatiello et al. 1998	Post mortem study of brain tissue	18/18	^↓PFC, HIP, CN, CBL	n/a	n/a	p<0.02 vs. controls
Giodotti et al. 2000	Post mortem study of brain tissue	15/15	^↓PFC, CBL	n/a	n/a	p<0.001 vs. controls in PFC
Giodotti et al. 2000	Post mortem study of brain tissue	15/15	^↓PFC, CBL	n/a	n/a	p = 0.02 vs. controls in cerebellum
Zhubi et. al 2009	Post mortem study of brain tissue	6/7	n/a	n/a	^↑ PFC	p = 0.007 vs. controls
Zhubi et. al 2009	Analysis of blood cells in vivo	22/24	n/a	n/a	^↑ PBL	p = 0.001 vs. controls
Giodotti et al. 2007	Post mortem study of brain tissue	14/15	n/a	n/a	^↑PFC	p = 0.005 vs. controls
Veldic et al. 2005	Post mortem study of brain tissue	19/26	n/a	n/a	^↑PFC	p<0.001 vs. controls
Veldic et al. 2004	Post mortem study of brain tissue	7/8		n/a	^↑PFC	p = 0.025 vs. controls
Veldic et al. 2004			^↓PFC			p<0.05 vs. controls
Fatemi et al. 2001	Analysis of blood RELN level in vivo	16/8	n/a	^↑	n/a	p = 0.02 vs. controls for 410 kDa F.

[Altered Reelin levels in blood and brain tissue in schizophrenic patients (S) vs. healthy controls (C); Conc = Concentration, GCN = Gabaergic Cerebral (Inter-) Neuron, PFC = Prefrontal Cortex, HIP = Hipocampus, CN = caudate nucleus, CBL = Cerebellum, PBL = Peripheral Blood Lymphocytes

↓ = decrease

↑ = increase, n/a = not applicable].