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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Hepatology. 2015 Jul 30;62(3):915–931. doi: 10.1002/hep.27909

Figure 6. Schematic of the role mesnechyme-mediated immune control (MMIC) mechanism in peripheral T cell tolerance.

Figure 6

Self-reactive T cells escaped from the negative selections in thymus are activated by the cognate antigens in the periphery, produce IFN-γ, and trigger the IFN-γ signaling pathways in mesenchymal cells, resulting in B7-H1 expression to induce Tef cell apoptosis, and production of the soluble factors to promote generation of MDSC and Treg cells. Autoreactive T cell response is thus inhibited in periphery.