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. 2015 Aug 25;10(8):e0136566. doi: 10.1371/journal.pone.0136566

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© 2015 Schmitz-Rohmer et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — (A) Changes in transcript levels between wild-type and Ndr1/2-double null embryos at E8.5 as revealed by microarray analysis (see S1 and S2 Tables). (B) Validation of the alterations in p21 and p27 expression in wild-type (control) and Ndr1/2-double null embryos by qRT-PCR (at E8.5). Data shown represent the average gene expression levels obtained by analyzing three independent embryos per genotype. Each embryo was analyzed in triplicate. Statistical analysis was performed using a two-tailed Student t-test assuming unequal variance. (C) Genotype distribution of offspring from Ndr1 ^+/-;Ndr2 ^-/-;p21 ^+/- intercrosses. Embryos were isolated at E8.5 and genotyped. Top panel: p21 genotype of the Ndr1/2-double null embryos; bottom panel: Ndr1 genotype of the p21-null embryos. The p-values are indicative of the probabilities to obtain the observed genotype distribution by chance.