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. 2015 Aug 25;10(8):e0135410. doi: 10.1371/journal.pone.0135410

Fig 1. PARP-1 binds promoters of active genes.

Fig 1

Midpoints of the reads of PARP1-associated nucleosomes were plotted against distance from TSSs. PARP-1 associates with highly transcribed gene TSS’s (solid red line), and not with promoters of low expressed or repressed gene promoters (solid blue) in (A) MCF7 cells and (B) MDA-MB231 cells. All genes were ranked by level of expression in both MCF7 and MDA-MB231 cells and sorted into deciles from lowest to highest. Mapping of PARP1 association show increased PARP-1 enrichment at TSS as level of gene expression increases in (C) MCF7 and (D) MDA-MB231 cells.