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(A) PARP1 associates with genomic regions containing specific histone modifications. Genomic locations of various histone modifications were mapped on PARP-1 bound regions of the human genome. Solid green, red, blue, orange and black lines represent PARP-1 alignment with H3K4me3, H3K36me3, H3K27ac, H3K27me3, and H3K9me3 modifications in MCF7 and MDA-MB231 cells. (B) PARP1 also binds to DNase hypersensitive sites in both cell types.
